McAuley et al., Stem Cells, 2019
Congrats to Erin et al. for her recent paper published in Stem Cells. URL here
- Lineage-tracing of Sox2-positive cells in the prostate demonstrates that they are long-lived and multipotent.
- Sox2-positive cells survive castration, and contribute to epithelial regeneration.
- Persisting Sox2-positive luminal cells are castration-resistant.
Bhanvadia and VanOpstall et al., Clinical Cancer Research, 2018
Congrats to Raj et al. for their recent paper published in Clinical Cancer Research. URL here
- 11% of prostate tumors are MEIS-positive; MEIS-positive tumors are associated with decreased PSA-recurrence and metastasis.
- MEIS high tumors are associated with decreased proliferation, increased adhesion, and increased differentiation.
- Knockdown of both MEIS1 and MEIS2 in prostate cancer cells renders them more tumorigenic.
McAuley et al., American Journal of Pathology, 2017
Congrats to Erin et al. for their recent paper published in AJP. URL here
- Longitudinal MRI quantified prostatic enlargement of mouse prostates treated with combined testosterone + estrogen.
- Enlarged prostates did not have increased immune cell invasion, but did have significantly decrease rates of cell death.