News
New Paper in eLife from the VG Lab!
Congrats to Calvin for the acceptance of his paper in eLife! The title of the paper is "MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans." This was a great team effort, and thank you to everyone who contributed.
Check out the paper here: https://elifesciences.org/articles/53600
Congrats to Dr. Srikanth Perike for being awarded an AUA Research Scholar Grant!
Dr. Perike's project entitled "Role of MEIS Proteins as HOXB13-Dependent Inhibitors of Prostate Cancer Metastasis and Androgen Receptor Signaling” received a 2-year award from the AUA and Urology Care Foundation. Congrats!
Congrats to Dr. Larischa DeWet for Defending Her Thesis!
Dr. DeWet successfully defended her dissertation at the University of Chicago with family, friends, and co-workers present. We're proud of her but sad that she'll soon become a lab alumnus.
Society for Basic Urologic Research (SBUR), November 2019, New Orleans
Was great to see Dr. Steve Kregel and hang out with Lari and Dan at the SBUR meeting in New Orleans. Was a great meeting.
Congrats to Calvin for New Baby VanOpstall!
Congrats to Calvin and Kendra for their amazing and beautiful daughter! So happy and proud for the new parents.
Congrats to Dr. Calvin VanOpstall for Defending his Thesis!
McAuley et al., Stem Cells, 2019
Congrats to Erin et al. for her recent paper published in Stem Cells. URL here
Key Findings:
- Lineage-tracing of Sox2-positive cells in the prostate demonstrates that they are long-lived and multipotent.
- Sox2-positive cells survive castration, and contribute to epithelial regeneration.
- Persisting Sox2-positive luminal cells are castration-resistant.
Bhanvadia and VanOpstall et al., Clinical Cancer Research, 2018
Congrats to Raj et al. for their recent paper published in Clinical Cancer Research. URL here
Key Findings:
- 11% of prostate tumors are MEIS-positive; MEIS-positive tumors are associated with decreased PSA-recurrence and metastasis.
- MEIS high tumors are associated with decreased proliferation, increased adhesion, and increased differentiation.
- Knockdown of both MEIS1 and MEIS2 in prostate cancer cells renders them more tumorigenic.
Society for Basic Urologic Research (SBUR), November 2018, Palm Springs
Congrats to Dan and Calvin for their poster presentations at the SBUR in Palm Springs, CA. Program found here.
McAuley et al., American Journal of Pathology, 2017
Congrats to Erin et al. for their recent paper published in AJP. URL here
Key Findings:
- Longitudinal MRI quantified prostatic enlargement of mouse prostates treated with combined testosterone + estrogen.
- Enlarged prostates did not have increased immune cell invasion, but did have significantly decrease rates of cell death.