McAuley et al., Stem Cells, 2019

Congrats to Erin et al. for her recent paper published in Stem Cells. URL here

Key Findings:

  • Lineage-tracing of Sox2-positive cells in the prostate demonstrates that they are long-lived and multipotent.
  • Sox2-positive cells survive castration, and contribute to epithelial regeneration.
  • Persisting Sox2-positive luminal cells are castration-resistant.

Bhanvadia and VanOpstall et al., Clinical Cancer Research, 2018

Congrats to Raj et al. for their recent paper published in Clinical Cancer Research. URL here

Key Findings:

  • 11% of prostate tumors are MEIS-positive; MEIS-positive tumors are associated with decreased PSA-recurrence and metastasis.
  • MEIS high tumors are associated with decreased proliferation, increased adhesion, and increased differentiation.
  • Knockdown of both MEIS1 and MEIS2 in prostate cancer cells renders them more tumorigenic.

Society for Basic Urologic Research (SBUR), November 2018

Congrats to Dan and Calvin for their poster presentations at the SBUR in Palm Springs, CA. Program found here.

McAuley et al., American Journal of Pathology, 2017

Congrats to Erin et al. for their recent paper published in AJP. URL here

Key Findings:

  • Longitudinal MRI quantified prostatic enlargement of mouse prostates treated with combined testosterone + estrogen.
  • Enlarged prostates did not have increased immune cell invasion, but did have significantly decrease rates of cell death.